[Quantum-pharmacological aspects of cardiovascular drugs studying].

Quantum pharmacology allows to study the mechanisms of action of cardiovascular drugs, to predict pharmacological activity and identify the most pronounced pharmacodynamic efficacy and therapeutic activity of new compounds. Calculation of quantum-pharmacological parameters for molecules of beta-blockers (propranolol, atenolol, metoprolol, carvedilol) in aqueous media, research its hydrophobic interaction with receptors allow to form a theoretical basis for the development of new generations of more effective and safe medicines for hypertension treatment. Increased hydrophobicity leads to poor solubility of carvedilol in water and high--in the lipids.

[Effect of carvedilol in the combination with quercetine and tiotriazoline on the nucleus density and RNA concentration in the nucleus of cardiac myocytes of spontaneous hypertensive rats].

It was found out in the previous studies, that rats with spontaneous hypertension (SHR) developed the hypertrophy of myocardium, disorders of osmotic properties of erythrocytes membranes, morphological and ultrastructural changes in the cardiac hystiocytes of animals. Carvedilol in SHR rats has decreased blood pressure, and normalized physiological, biochemical and morphological indexes in the cardiac muscle. More expressed effect was observed during the use of carvedilol with metabolic medications--Quercetine and Tiotriazoline.

[Influence of lipril on the myocardial ultrastructure in rats with spontaneous hypertension].

In the spontaneous hypertensive rats (SHR)--line NISAG--most cardiac hystiocytes of the left ventriculum have signs of ultrastructure damage to a variable extent. First of all the contractile and energetic function of cardiac hystiocytes has different abnormalities. Administration of Lipril (20 mg/kg daily, during three months) showed the normalization of the ultrastructure of myocardium of SHR.

[Study of quantum-pharmacological chemical characteristics of quercetin].

It was established in the previous studies that quercetin prevented the development and caused faster regression of ulcers, petechia and anabroses in rats, which were induced by diclofenac taking. In the group of patients taking diclofenac together with quercetin, the ulcers and dyspeptic events were less found. The application of quercetin normalizes the function and metabolism of cartilage tissue of rabbits with an experimental osteoarthrosis and in patients with osteoartrosis.

[Molecule of taurine and its quantum-pharmacological properties].

Quantum-pharmacological properties of taurine and its zwitterion form have been studied. Geometrical and energetic parameters were calculated using ab initio 6-31G* technique. These parameters are the following: distance between atoms, distribution of electronic density only of external valency electrons, distribution of electrostatic potential, atomic charges, dipole moment, localization and energy of high and low occupied and low unoccupied molecular orbitals.