Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis.

Starting from benzyl 30-oxobetulinate and 30-oxobetulin diacetate, substituted dienes were synthesized and subjected to Diels-Alder reaction, yielding a variety of triterpenoid phthalates, phthalimides, and related derivatives. A total of 55 new compounds were prepared and tested for in vitro cytotoxic activity against eight cancer cell lines and two non-cancerous cell lines. Four compounds with IC values of 5 μM or lower were selected for further investigation.

Expensive today but cheaper tomorrow: lifetime costs of an active middle ear implant compared to alternative treatment options.

Background: When choosing between different treatment options, implants often appear too costly. However, this perspective does not take future costs into account. This article evaluates lifetime costs for different surgical interventions to treat hearing loss.

Climate change extinctions.

Climate change is expected to cause irreversible changes to biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections to produce a quantitative global assessment of climate change extinctions. With increased certainty, this meta-analysis suggests that extinctions will accelerate rapidly if global temperatures exceed 1.

Global language geography and language history: challenges and opportunities.

As the several thousand languages spoken by people all around the world became more and more systematically assessed and catalogued in the 20th century, it became clear that linguistic diversity is unevently distributed across the globe. Up to the present day, the reasons for that are poorly understood. Linguists are thus in the embarassing situation that they do not understand significant regularities in the way the objects of their study -languages- pattern; human sciences at large are faced with the fact that the way humans produce that key cultural product which is often seen as defining the essence of what makes them humans -language-remains in the dark.