[A role of the adhesive properties of leucocytes and blood serum in the pathogenesis of multiple sclerosis].

Adhesive properties of leucocytes were studied using an original technique based on the leukocyte adherence inhibition reaction and measuring the values of spontaneous adhesion index (SAI) and adhesion-strengthening effect (ASE) under the influence of autoserum. One hundred patients with multiple sclerosis (MS) and 53 controls were included in the study. Immunophenotyping of lymphocytes (LP) with monoclonal antibodies--markers CD3, CD4, CD8, CD16, CD20, CD25, HLA-DR and CD95--and determination of IgG, IgA, IgM and content of immune complexes were carried out in parallel.

[Clinical significance of adhesive properties of leukocytes and blood serum in patients with multiple sclerosis].

Adhesive blood properties have been studied in 100 MS patients with the help of the new method developed on the basis of the leucocyte adherence inhibition (LAI) test, which was based on the calculation of the ratio of adhesive cells to non-adhesive ones. The value obtained was called the Index of Spontaneous Adhesion (ISA), while the respective indicator reflecting the effect of adhesion strengthening under the influence of autoserum, being expressed by 30% and more, was named the Effect of the Adhesion Strengthening (ES-a). Blood samples of 54 donors and 31 patients with other neurological diseases were used as controls.

[The role of serum 'adhesive factor' and leukocyte sensitization in pathogenesis of multiple sclerosis].

The reactivity to the myelin basic protein, brain gangliosides purified derivative and also the influence of the serum on the cells adherence were determined by micromodification of the leukocyte adherence inhibition (LAI) test. 46 multiple sclerosis patients, 21 patients with hereditary disease and 41 donors were examined. The cellular sensitization to the myelin basic protein and brain gangliosides was revealed in 57% of the multiple sclerosis patients.

[The characteristics of changes in the hemodynamics and respiratory function of children with severe closed abdominal trauma].

Out of 566 children with closed abdominal trauma, treated in the EMI "Pirogov" over a five-year period, 79 present serious impairment of the basic vital functions (respiration, hemodynamics and the like) connected with the trauma and not infrequently with massive blood loss, necessitating the undertaking of resuscitation measures and intensive care. Of the latter 67 are restored to health, and in twelve the outcome is fatal. In terms of hemodynamic parameters a significant tachycardia along with maintaining normal or even increased arterial pressure are the most characteristic, whereas hypotension is present in 6.

[Traumatic lesions of the thoracic and abdominal organs in childhood].

This is a retrospective analysis of 651 children, aged 0 to 14 years, presenting chest and abdominal injuries, treated over a 6-year period in the section of pediatric surgery of the Emergency Medicine Institute "Pirogov". The results of studies on the etiopathogenesis of chest and abdominal trauma, patterns of associated lesions and quality of prehospital aid are discussed. Experience with the application of updated noninvasive and invasive methods of diagnosis, as well as the scope of surgical approach to the variety of lesions by resorting to organ sparing and organ salvaging operative procedures are analyzed.