Publications by authors named "M I Tepper"
The Development of a Brief but Comprehensive Therapeutic Assessment Protocol for the Screening and Support of Youth in the Community to Address the Youth Mental Health Crisis.
Brain Sci
November 2024
Article Synopsis
- The study aimed to assess the acceptability and feasibility of the Screening and Support for Youth (SASY), a community-based program that provides mental health screening and support for diverse youth.
- Using various tools, the SASY screening evaluated symptoms, functioning, and clinical risks, leading to personalized insights for participants during motivational interviews and options for online interventions.
- Innovative recruitment methods, enhanced by the pandemic (like using QR codes), successfully increased participation, particularly among Black or African American and Hispanic youth, showing that combining online and offline strategies can effectively engage a diverse population.
Many patients do not experience optimal benefits from medical advances because clinical research does not adequately represent them. While the diversity of biomedical research cohorts is improving, ensuring that individual patients are adequately represented remains challenging. We propose a new approach, GenoSiS, which leverages machine learning-based similarity search to dynamically find patient-matched cohorts across different populations quickly.
View Article and Find Full Text PDFThe behavioral health workforce has been experiencing deepening problems with recruitment and retention, particularly in publicly funded settings serving individuals with serious mental illnesses. This quality improvement project gathered Assertive Community Treatment (ACT) participant (service user) and provider perspectives on workforce challenges. The authors conducted 8 interviews with ACT participants and 9 focus groups with ACT current staff, team leaders, and former staff.
View Article and Find Full Text PDFBackground: Assessments of gaze direction (eye movements), pupil size, and the pupillary light reflex (PLR) are critical for neurological examination and neuroscience research and constitute a powerful tool in diverse clinical settings ranging from critical care through endocrinology and drug addiction to cardiology and psychiatry. However, current bedside pupillometry is typically intermittent, qualitative, manual, and limited to open-eye cases, restricting its use in sleep medicine, anesthesia, and intensive care.
Methods: We combined short-wave infrared (SWIR, ~0.
Article Synopsis
- Tourette syndrome is a movement disorder linked to basal ganglia dysfunction, and PDE10A inhibitors, like EM-221, may help treat it.
- EM-221 effectively inhibited PDE10A in lab tests and showed promise in reducing hyperactivity and other behavioral issues in rats, with good safety profiles in both rats and dogs.
- The study supports moving forward with phase 2 trials for EM-221 in humans with Tourette syndrome and related disorders, as it demonstrated high enzyme occupancy and tolerability.