Influence of Apoptotic Bodies and Apoptotic Microvesicles on NO Production in Macrophages.

We studied the effect of extracellular vesicular particles generated during apoptosis by macrophages of M0, M1 and M2 phenotypes on spontaneous and LPS-stimulated production of NO. The fractions of apoptotic bodies and apoptotic microvesicles were obtained in the primary cultures of peritoneal macrophages undergoing apoptosis. The effect of these microparticles on LPS-induced proinflammatory response of recipient macrophages critically depends on the initial phenotype of "donor" macrophages.

[Influence of cholesterol on macrophage foam cells formation at zymosan-induced inflammation of mice].

It has been shown recently that significant number (to 40% from total population) of macrophage foam cells (MFC) is formed during early time (24 h) of zymosan-induced peritonitis resolution and agonists of peroxisome proliferation activated receptors-α, -γ (PPAR-α, -γ) exert anti-inflammatory action, protecting their formation (Dushkin et al., 2007). The work is devoted to investigate of the influence of cholesterol-containing liposomes (CHL) on dinamic of zimozan-induced peritonitis in C57Bl/6 mice.

[Radiologic evaluation of effectiveness of physical training in patients with myocardial infarction].

The findings of two-projection large-image fluorography of the thorax of 134 men aged 32 to 60 with a history of myocardial infarction are presented. Physical rehabilitation of these patients was either traditional (controls) or enhanced by physical training (test group). X-Ray characteristics of the pulmonary vascular bed help to detect left ventricular insufficiency even in cases when there are no clinical symptoms of it.

[Possibilities of improving medical and socioeconomic effectiveness of the treatment of patients with myocardial infarct by physical training during posthospital stage of rehabilitation].

Two groups of patients with myocardial infarction were compared for outcomes of rehabilitation. In group 1, rehabilitative therapy was performed by using conventional methods. In group 2, that was done on the basis of early activation and application of physical trainings 2 weeks following myocardial infarction.

[Effects of physical training on tolerance of psychoemotional stress in patients with myocardial infarct].

Intensive physical training were examined for their impact on tolerance for information loading at various stages of restorative therapy in 62 males of productive age who had extensive myocardial infarction. It was established that the physical training performed at the hospital stage reduced the incidence of ischemic responses to information loading at all stages of restorative therapy. At the same time the physical training in patients with myocardial infarction promote higher frequency of ischemic angiospastic responses during the information test.