Tryptophan Prevents the Development of Non-Alcoholic Fatty Liver Disease.

Purpose: The main aim of this research is to study the protective effects of tryptophan on the histomorphological and biochemical abnormalities in the liver caused by a high-calorie diet (HCD), as well as its ability to normalize mitochondrial functions in order to prevent the development of non-alcoholic fatty liver disease (NAFLD).

Methods: The study was conducted in male Wistar rats aged 3 months at the start of the experiment. Control animals (group I) were fed a standard diet.

[SEASONAL DIFFERENCES IN THE EFFECT OF MELATONIN ON THE MORPHO-FUNCTIONAL STATE OF THE THYROID GLAND SPONTANEOUSLY HYPERTENSIVE RATS].

We studied the effect of exogenous melatonin on the indicators of thyroid gland condition of the young spontaneously hypertensive rats in spring and autumn. These data suggested that after 28-day of melatonin administration (5 mg/kg) in different seasons of the year there were divergent effects on the state of the thyroid gland. So, melatonin increased synthetic activity of the gland in the spring.

[EFFECT OF MELATONIN ON AGE-RELATED DYNAMICS OF THE REACTIVE PROPERTIES OF BONE TISSUE].

The effect of melatonin (MT) on the bone tissue (BT) reactive properties was investigated among 80 male Wistar rats at the age of 3, 9, 12 and 16 months. The reactive properties of BT were judged by its ability to polarization under the influence of the alternating electric current. The value of reactance at the frequency of maximum polarization was used as the indicator of BT reactivity.

[Effect of dosed diet restriction on physiological remodeling and bioelectric properties of bone].

The effect of dosed diet restriction on the physiological remodeling and bioelectric properties of bone tissue was studied in 48 male Wistar rats 3- and 18-months of age. The rate of bone tissue apposition was studied by the dynamic histomorphometry method (intravital tetracycline labeling). Electric potentials on the periosteal surface of the freshly isolated femurs were recorded.

[The influence of hyperoxic gas mixture on the respiratory part of the lungs in rats].

The respiratory part of the lungs was investigated in rats of 3 and 12 months of age before and after the influence of normobaric hyperoxic gas mixture (40 % and 90 % oxygen). We found the reduction in middle diameter, depth, cross-sectional area, width of the entrance to alveolus and the total width of respiratory bronchioles, alveolar ducts and sacs after 28 daily hyperoxic sessions (60 mines each). We detected increasing the amount of collagen fibers, the alveolar wall thickness and oxyproline concentration in a lung after breathing the hyperoxic gas mixture.