stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments.

Introduction: Tuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. However, this diverse modeling panorama may lack consistency, limiting result comparability.

Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms.

Glucocorticoids (GCs) are standard-of-care treatments for inflammatory and immune disorders, and their long-term use increases the risk of osteoporosis. Although GCs decrease bone functionality, their role in bone microvasculature is incompletely understood. Herein, the study investigates the mechanisms of bone microvascular barrier function via osteoblast-endothelial interactions in response to GCs.

Tracheal, bronchus, and lung cancer mortality and air pollution exposure in Tuscany, Italy: Bayesian Health Impact Assessment and Global Sensitivity Analysis on a sub-regional scale.

Outdoor air pollution is a significant risk factor for tracheal, bronchus, and lung (TBL) cancer. This study employs a Bayesian approach to evaluate TBL cancer mortality due to air pollution in Tuscany, Central Italy, in 2023. Using locally validated data, we assessed the impact of fine particulate matter (PM and PM) and nitrogen dioxide (NO) in terms of attributable deaths and years of life lost (YLL).

TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney.

Epithelial sodium channel (ENaC), located in the collecting duct principal cells of the kidney, is responsible for the reabsorption of sodium and plays a critical role in the regulation of extracellular fluid volume and consequently blood pressure. The G protein-coupled bile acid receptor (TGR5) is a membrane receptor mediating effects of bile acid and is implicated in kidney diseases. The current study aims to investigate whether TGR5 activation in the kidney regulated ENaC expression and potential mechanism.

Replacing serum with dried blood microsampling for pharmacokinetics, viral neutralisation and immunogenicity bioanalysis supporting future paediatric development of RSM01, a candidate respiratory syncytial virus neutralising monoclonal antibody.

Background: Virus neutralising antibodies in serum are considered key correlates of protection for vaccines and monoclonal antibodies against respiratory syncytial virus (RSV). RSM01 is a novel, highly-potent, half-life-extended and fully-human monoclonal antibody candidate targeting the RSV prefusion F protein. Currently in Phase 1 development, RSM01 is primarily being developed to potentially provide an effective and affordable RSV prevention strategy in low- and middle-income countries.