Polypropylene Crystallinity Reduction through the Synergistic Effects of Cellulose and Silica Formed via Sol-Gel Synthesis.

This study focuses on the development of environmentally sustainable polypropylene (PP)-based composites with the potential for biodegradability by incorporating cellulose and the oligomeric siloxane ES-40. Targeting industrial applications such as fused deposition modeling (FDM) 3D printing, ES-40 was employed as a precursor for the in situ formation of silica particles via hydrolytic polycondensation (HPC). Two HPC approaches were investigated: a preliminary reaction in a mixture of cellulose, ethanol, and water, and a direct reaction within the molten PP matrix.

Non-Coagulant Spinning of High-Strength Fibers from Homopolymer Polyacrylonitrile Synthesized via Anionic Polymerisation.

The rheological properties, spinnability, and thermal-oxidative stabilization of high-molecular-weight linear polyacrylonitrile (PAN) homopolymers (molecular weights = 90-500 kg/mol), synthesized via a novel metal-free anionic polymerization method, were investigated to reduce coagulant use, enable solvent recycling, and increase the carbon yield of the resulting carbon fibers. This approach enabled the application of the mechanotropic (non-coagulating) spinning method for homopolymer PAN solutions in a wide range of molecular weights and demonstrated the possibility of achieving a high degree of fiber orientation and reasonable mechanical properties. Rheological analysis revealed a significant increase in solution elasticity (G') with increasing molecular weight, facilitating the choice of optimal deformation rates for effective chain stretching prior to strain-induced phase separation during the eco-friendly spinning of concentrated solutions without using coagulation baths.

Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions.

Background: To assess the pharmacokinetic correlates of reported adverse drug reactions (ADRs) under antidepressant treatment with escitalopram (ESC) using a large therapeutic drug monitoring database.

Methods: A large naturalistic sample of inpatients and outpatients prescribed ESC was analyzed. ADRs were classified using the Udvalg for Kliniske Undersogelser side effect rating scale.

Switching antipsychotics to partial dopamine D2-agonists in individuals affected by schizophrenia: a narrative review.

Objective: The aim of this review is to analyse the literature regarding studies centred on the clinical outcome of individuals affected by schizophrenia and treated with various antipsychotics, and then switched to orally administered partial D2-dopamine agonists (PD2A): Aripiprazole (ARI), brexpiprazole (BREX) or cariprazine (CARI).

Method: A PubMed literature search was performed on 16 February 2021, and updated on Jan 26, 2022 for literature on antipsychotic switching in individuals affected by schizophrenia. Literature was included from 2002 onward.