Burr hole microsurgical subtemporal selective amygdalohippocampectomy.

Introduction: At present, selective amygdalohippocampectomy (SAH) has become popular in the treatment of drug-resistant mesial temporal lobe epilepsy (TLE). However, there is still an ongoing discussion about the advantages and disadvantages of this approach.

Methods: The study included a consecutive series of 43 adult patients with drug-resistant TLE, involving 24 women and 19 men (1.

[Neurophysiological aspects of multiple hippocampal transection in intractable temporal lobe epilepsy].

Objective: To search for correlations between intraoperative electrocorticographic data and seizure control after the multiple hippocampal transections (MHT) in patients with symptomatic pharmacoresistant medial temporal lobe epilepsy.

Material And Methods: Six patients underwent MHT nearby the hippocampus. The left dominant hemisphere was affected in all cases.

[Surgical treatment of drug-resistant epilepsy following hippocampal sclerosis].

Unlabelled: Surgery is an effective approach for drug-resistant temporal lobe epilepsy following hippocampal sclerosis. There is still no clear and unanimous opinion about advantages and disadvantages of certain surgical technique.

Material And Methods: There were 103 surgical interventions in 101 patients.

Multiple hippocampal transections for mesial temporal lobe epilepsy.

Background: The purpose of this study was to evaluate the effectiveness of multiple hippocampal transections (MHT) in the treatment of drug-resistant mesial temporal lobe epilepsy.

Methods: Six patients underwent MHT at Burdenko Neurosurgery Center in 2018. The age of the patients varied from 18 to 43 years.

GH/IGF-I/insulin system in centenarians.

The endocrine system plays a major role in the regulation of several biological activity and in the ageing process. Evolutionary conservation of GH/IGF-I/insulin pathway from worms to mice and similarities in this system between mice and humans raised expectations that downregulated activity of the GH/IGF-I/insulin pathway could be beneficial for the extension of human life span. Centenarians represent the best example of successful ageing having reached the very extremes of the human life span, escaping and delaying the occurrence of several fatal age-related diseases, such as cancer and cardiovascular diseases.