Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases.

Acetyl coenzyme A (acetyl-CoA), a pivotal regulatory metabolite, is a product of numerous catabolic reactions and a substrate for various anabolic responses. Its role extends to crucial physiological processes, such as glucose homeostasis and free fatty acid utilization. Moreover, acetyl-CoA plays a significant part in reshaping the metabolic microenvironment and influencing the progression of several diseases and conditions, including cancer, insulin resistance, diabetes, heart failure, fear, and neuropathic pain.

Frequency and Predictors of Diabetes Mellitus in Smear-Positive Pulmonary Tuberculosis Patients: A Cross-Sectional Study.

Introduction Tuberculosis (TB) is an infectious disease caused by . Various studies have established an association between diabetes mellitus (DM) and pulmonary TB. This study describes the prevalence of DM and its predictors in smear-positive TB patients.

Prevalence and associated risk factors of musculoskeletal disorders among information technology (IT) professionals: A systematic review.

Musculoskeletal disorders (MSDs) are a growing concern among information technology (IT) professionals. Understanding the specific risk factors associated with MSDs among employers, occupational health practitioners, and IT professionals may reveal effective preventive measures. The aim of this study was to examine the prevalence and identify the risk factors associated with MSDs among IT professionals.

Waste-derived substrates in vertical-flow constructed wetlands for an efficient removal of high-concentration heavy metals.

Contamination by heavy metals (HMs) in aquatic ecosystems is a worldwide issue. Therefore, a feasible solution is crucial for underdeveloped and developing countries. Waste-derived materials (WDMs) exhibit unique physical and chemical properties that promote diverse mechanisms for the removal of HMs in constructed wetlands (CWs).

Influence of spousal educational disparities on intimate partner violence (IPV) against pregnant women: a study of 30 countries.

Intimate Partner Violence (IPV) during pregnancy poses a serious threat to maternal health, particularly in low- and lower-middle-income countries (LMICs). Despite these known risks, the role of spousal educational differences in IPV during pregnancy remains poorly understood. This study aimed to examine this influence, analyzing data from multiple countries across five continents.