Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties.

Neurodegenerative diseases are disabling, incurable, and progressive conditions characterized by neuronal loss and decreased cognitive function. Changes in gut microbiome composition have been linked to a number of neurodegenerative diseases, indicating a role for the gut-brain axis. Here, we show how specific gut-derived bacterial strains can modulate neuroinflammatory and neurodegenerative processes through the production of specific metabolites and discuss the potential therapeutic implications for neurodegenerative disorders.

Bifidobacterium breve MRx0004 protects against airway inflammation in a severe asthma model by suppressing both neutrophil and eosinophil lung infiltration.

Asthma is a phenotypically heterogeneous disease. In severe asthma, airway inflammation can be predominantly eosinophilic, neutrophilic, or mixed. Only a limited number of drug candidates are in development to address this unmet clinical need.

Human Gut Symbiont Promotes and Regulates Innate Immunity.

Objective: is a flagellated gut anaerobic bacterium belonging to the family within the Firmicutes phylum. A significant decrease of colonization in the gut of ulcerative colitis patients has recently been demonstrated. In this work, we have investigated the mechanisms of -host cross talk using both murine and models.