Leveraging plant-derived nanovesicles for advanced nucleic acid-based gene therapy.

Gene therapy has evolved into a pivotal approach for treating genetic disorders, extending beyond traditional methods of directly repairing or replacing defective genes. Recent advancements in nucleic acid-based therapies-including mRNA, miRNA, siRNA, and DNA treatments have expanded the scope of gene therapy to include strategies that modulate protein expression and deliver functional genetic material without altering the genetic sequence itself. This review focuses on the innovative use of plant-derived nanovesicles (PDNVs) as a promising delivery system for these nucleic acids.

Medicago2035: Genomes, Functional Genomics and Molecular Breeding.

Medicago, a member of the Leguminosae or Fabaceae family, encompasses the most significant forage crops globally, notably alfalfa (Medicago sativa L.). Its close diploid relative, Medicago truncatula, serves as an exemplary model plant for investigating leguminous growth and development, as well as its symbiosis with rhizobia.

Application of autophagy in mesenchymal stem cells.

In this editorial, we have taken an in-depth look at the article published by Wan . The study showed that preconditioning mesenchymal stem cells (MSCs) protected them against programmed cell death, and increased their survival rate and therapeutic potential. Autophagy, a type of programmed cell death, is a major intracellular degradation and recycling pathway that is crucial for maintaining cellular homeostasis, self-renewal, and pluripotency.

Astrogliosis and glial scar in ischemic stroke - focused on mechanism and treatment.

Ischemic stroke is a kind of neurological dysfunction caused by cerebral ischemia. Astrocytes, as the most abundant type of glial cells in the central nervous system, are activated into reactive astrocytes after cerebral ischemia, and this process involves the activation or change of a series of cell surface receptors, ion channels and ion transporters, GTPases, signaling pathways, and so on. The role of reactive astrocytes in the development of ischemic stroke is time-dependent.

Cloning the promoter of the sucrose transporter gene PsSUT2 and screening its upstream transcription factors in tree peony.

Sucrose is an essential energy substance for tree peony (Paeonia Suffruticosa) floral organ development. However, little is known about the sucrose regulatory network in tree peony. In this study, the promoter sequence of the tree peony sucrose transporter gene PsSUT2 was cloned.