[COMBINATION OF TAURINE WITH ZINC DIASPARTATE FOR CORRECTION OF METABOLISM DISTURBANSES IN NEPHRONS AND RENAL FUNCTION IN RATS WITH CONTRAST-INDUCED NEPHROPATHY].

The nephroprotective properties of a combination of taurine with zinc diaspartate (taucin) in rats with contrast-induced nephropathy have been estimated. It is established that the combination of taurine with zinc diaspartate (20 and 1 g/mol, respectively, ingested in doses 250 and 500 mg/kg in the stomach during 14 days) produces a dose-dependent nephroprotective action on rats with contrast-induced (sodium and meglumin amidotrizoates, 800 mg/kg/day intraperitoneally, 14 days) nephropathy.

[Therapeutic effect of acetylcysteine on rats with gentamicin-induced nephropathy].

Gentamicin (60 mg/kg, i.p., once per day for 10 days) produces a nephrotoxic effect in rats, which is manifesting by the epithelium necrosis of proximal convoluted tubules (especially of cortical nephrons), decreasing creatinine clearance, and increasing protein in the urine.

[Comparative analysis of the role of individual peculiarities of kidney structure in predisposition to the nephrotoxicity of gentamicin in intact and hydronephrotic rabbits].

Comparative analysis of relationships between individual peculiarities of the structure of nephrons in intact and hydronephrotic right rabbit kidneys, on one hand, and the degree of expression of nephrotoxicity of gentamicin with respect to the only intact and as well hydronephrotic left kidney, on the other hand, was undertaken. Damage of the kidney by this antibiotic is more expressed in rabbits with smaller diameter of distal convoluted tubules of nephrons and smaller size of the cells lining their lumen. These peculiarities of the structure of nephrons lead to predisposition to the gentamicin-induced nephropathy in intact rabbits to a higher degree than in animals with hydronephrosis.

[Individual activity of renal enzymes in the susceptibility of hydronephrotic rabbits to aminoglycoside (gentamicin) nephrotoxicity].

A correlation between the individual features of the activity of renal enzymes and the expression of aminoglycoside (gentamicin) induced nephrotoxicity is established in hydronephrotic rabbits. The level of gentamicin-induced damage of the kidney is more significant in rabbits with initially (prior to gentamicin administration) increased activity of lactate dehydrogenase, decreased activity of succinate dehydrogenase and acid phosphatase, and low content of ribonucleoproteins.

Role of individual structural features of rabbit kidneys in the predisposition to gentamicin nephrotoxicity.

A relationship between congenital features in the structure of rabbit kidneys and sensitivity to gentamicin nephrotoxicity was revealed. Gentamicin nephrotoxicity is more pronounced in rabbits with lower diameter of nephron convoluted tubules and with smaller cells lining their lumen.