[Development of concepts on the biochemistry and pharmacology of melanin pigments].

Biochemical principles of pharmacological action melanin, one of the natural cells pigments, are discussed. Melanin is involved into DNA-repair, in the the respiratory chain functioning; it modulates such important systems of the cellular metabolism as photo- end radio protectors. Melanin neutralizes the effect of products of lipid peroxidation and takes part in neurotransmitter processes under numerous pathological processes damaging functional neuron structures.

[A trial of the use of low-molecular-weight heparin (fraksiparin) in myocardial infarct].

Efficacy and safety were studied of nonfractionated versus low-molecular heparines (NFH, LMH) in acute myocardial infarction (AMI). A total of 99 AMI patients entered the trial including those after thrombolytic therapy. The highest preventive effect in respect to both venous and arterial thrombosis was achieved at subcutaneous administration of NFH in twice daily dose 12500 U and LMH in a single daily dose 25000 U.

[The modifying action of a complex of physiologically active substances isolated from the human amnion on chromosome damage].

It was determined that the complex of physiological active substances separated from human amnion reduced the frequency of the hepatocytes with chromosomal aberrations in rats. This reduction of chromosomal damages was noted at spontaneous and induced mutagenesis. The value of cytogenetical effect, the availability of raw material and the natural origin of the drug allow to propose it for further study and use as modifier of mutagenic action.