[Clinical evaluation of the effectiveness of manual toothbrushes with different brush field characteristics].

Nowadays an individual selection of personal care depending on the dental and hygiene human status is of great importance. The present study examines the clinical efficacy of toothbrushes with different characteristics of the brush field. The cleaning efficiency of toothbrushes with horizontal slant bristle and smooth cutting of the brush field is 75%, toothbrushes with a horizontal slant bristle and multilevel cutting of the brush field - 79%, toothbrushes with power bulge - 70% and toothbrushes with a flat brush field - 56%.

[Microbiological study of the efficiency of various hygienic products for toothbrushes].

Options vary about the microbial contamination of toothbrushes as well as selection of adequate remedies for their disinfection. A microbiological study of contamination of toothbrushes was conducted considering the efficiency of purifying tablets, ultraviolet radiation and 0.05% solution of chlorhexidine as means of toothbrushes disinfection.

p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G.

Many studies have suggested the involvement of wild-type (wt) p53 in the repair of DNA double-strand breaks (DSBs) via DNA end-joining (EJ) process. To investigate this possibility, we compared the capacity and fidelity of DNA EJ in RKO cells containing wt p53 and RKO cells containing no p53 (RKO cells with p53 knockdown). The p53 knockdown cells showed lower fidelity of DNA EJ compared to the control RKO cells.

Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes.

Bmi-1 is a member of the polycomb group (PcG) transcription repressors and is implicated in human carcinogenesis. In normal human oral keratinocytes (NHOK), we found that exogenous Bmi-1 expression significantly extended the replicative life span without causing cellular immortalization. Immortalization of NHOK occurs only in combination with human papillomavirus type 16 E6 (HPV-16 E6) but not with E7.