[The endocrinological aspects of cancer of the vulva].

Patients with cancer of the vulva showed significant disorders of pituitary adrenal cortex, ovarian and thyroid function. This requires carrying out corrective hormone therapy with the purpose of increasing the efficiency of combined treatment.

[Effect of hyperbaric oxygenation on the status of the renin-angiotensin-aldosterone system in chronic circulatory insufficiency in elderly patients with ischemic heart disease].

The study performed in 54 elderly patients with first and second degree chronic heart failure (CHF) during hyperbaric oxygenation (HBO) has revealed normalization of plasma renin activity, possibly, associated with improved renal blood flow. HBO also produced a drop in aldosterone concentration in patients with a high aldosterone level. However, the absence of changes in aldosterone concentration in the majority of ischemic patients with both first and second degree CHF during HBO gives evidence of its insignificant effect on adrenal mineralocorticoid activity.

[Changes in the renin-angiotensin-aldosterone system in the development of hypertension in aging. 2].

The change of the reactivity of the RAAS during physiological aging of the organism implies the variety of forms of the course of hypertension: The RAAS is involved in stage I of the development of the disease. The progress of the disease (stage III) results in the "decay" of the RAAS. A dependence of the activity of the RAAS on the clinical course and on the hemodynamic variant of hypertension in old age could detected.

[Change in the renin-angiotensin-aldosterone system in aging. 1].

Data are provided that testify to a changed reactivity of the RAAS in old age: Higher sensitivity of this system to the regulatory influences of the sympathico-adrenal and of the hypothalamus-hypophysis system as well as restriction of the functional facilities and reduction of reactivity. The obtained results indicate an aging-dependent reduction of the degree of reliability of the RAAS in stress situations.