[Use of superoxide dismutase in infusion therapy of experimental hemorrhagic shock].

The work deals with study of the possibility of increasing the efficacy of infusion therapy in massive blood loss by preliminary administration of superoxide dismutase (SOD). The data obtained bear evidence that in preliminary administration of SOD infusion of a blood substitute produces a more marked and stable improvement of central hemodynamics and microcirculation, oxygen regimen, and acid-base equilibrium in rats. A significant increase of the circulation volume and stroke volume of the heart following SOD injection may be linked with lesser intensity of lipid peroxidation in the cardiocyte membranes during reoxygenation.

[The effect of narcotic analgetic fenaridine and narcotic antagonist FI on the level of cyclic nucleotides in the brain of albino rats].

Content of cAMP and cGMP was estimated in rat brain corpus striatum after treatment with narcotic analgetic fenaridin and antagonist of narcotic analgetics F1 which are similar chemically. Various concentrations of fenaridin increased the cAMP content, whereas that of cGMP was not altered. At the same time, administration of the antagonist of narcotic analgetics F1 led to an increase in content of cGMP and to a distinct elevation of cAMP content.

[The effect of a superoxide dismutase compound on the level of endogenous superoxide dismutase and lipid peroxidation in thermal burns].

Content and activity of endogenous superoxide dismutase (SOD) were decreased simultaneously with an increase in the rate of lipid peroxidation under conditions of burns trauma. At the same time, parameters of the EPR signal were unaltered. Administration of exogenous SOD normalized the patterns studied and increased distinctly the survival rate of rats.