Intratumoral Treatment in Lung Cancer: Is It Time to Move Towards Clinical Practice?

According to a modern view, cancer no longer follows a purely mechanistic model. Rather, a tumor is conceived as a more complex structure, composed of cancer cells, the activities of which may interact and reshape the so-called tumor microenvironment (TME), leading to preservation of specific tumoral niches and promoting the survival of tumoral stem cells. : Therapeutic strategies must deal with this unique cancer architecture in the near future by widening their range of activities outside the cancer cells and rewiring a TME to ensure it is hostile to cancer growth.

Application of microarray patches for the transdermal administration of psychedelics drugs in micro-doses.

Throughout history, psychedelic compounds have been used for religious, spiritual and recreational purposes. A plethora of studies have reported the use of psychedelic compounds in the treatment of various conditions, such as alcoholism, addictions, depressive state to borderline schizophrenia, personality disorder, among other mental disorders. Psychedelic microdosing, a common technique in recent years, involves the consumption of small doses of psychedelic drugs for therapeutic purposes.

The Mediating Role of Emotion Regulation and Basic Psychological Needs: Association Between Childhood Trauma and Young Adults' Psychological Functioning from a Self-Determination Theory Perspective.

Numerous studies have shown the detrimental effects of childhood trauma on individuals' psychological functioning. This study examined the relation from childhood traumatic experiences to dissociation, life satisfaction, and attitude toward seeking psychological help while additionally shedding light on the possible mediating role of emotion regulation and basic psychological needs based on the framework of Self-Determination Theory (SDT). Using a cross-sectional design, data were collected from 489 Italian young adults (age = 23.

The Unique Challenge of Coronary Artery Disease in Adult Patients with Congenital Heart Disease.

Advances in medical and surgical interventions have resulted in a steady increase in the number of patients with congenital heart disease (CHD) reaching adult age. Unfortunately, this ever-growing population faces an added challenge: an increased risk of acquiring coronary artery disease. This review provides insight into the complex interactions between coronary artery disease and CHD in adults.

Proteolysis Targeting Chimera Agents (PROTACs): New Hope for Overcoming the Resistance Mechanisms in Oncogene-Addicted Non-Small Cell Lung Cancer.

Non-small cell lung cancer (NSCLC) remains a disease with a poor prognosis despite the advances in therapies. NSCLC with actionable oncogenic alterations represent a subgroup of diseases for which tyrosine kinase inhibitors (TKIs) have shown relevant and robust impact on prognosis, both in early and advanced stages. While the introduction of powerful TKIs increases the ratio of potentially curable patients, the disease does develop resistance over time through either secondary mutations or bypass activating tracks.