Publications by authors named "M Hynninen"
Article Synopsis
- Inhaled xenon combined with hypothermia was tested on comatose patients who survived out-of-hospital cardiac arrest (OHCA) to see if it could protect gray matter in the brain.
- A study of 110 patients found that those who received inhaled xenon and temperature management showed less reduction in brain gray matter volume, especially in areas like the amygdala and temporal gyrus, compared to those who received only temperature management.
- The results suggest that inhaled xenon can help preserve brain structure in this patient group, highlighting its potential therapeutic benefits.
Background: Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at least 10% absolute difference) of BI with usual care in reducing alcohol intake in intensive care unit survivors with history of hazardous alcohol use.
Methods: We used Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) score to assess history of alcohol use.
Background: We investigated the prevalence and effects of hazardous alcohol consumption on perioperative complications in cardiac surgery patients. Preoperative hazardous alcohol consumption has been associated with an increased risk of postoperative complications in noncardiac patient populations.
Methods: We retrospectively collected data from the Finnish Intensive Care Consortium database and electronic patient records on all cardiac surgery patients treated in the intensive care units (ICUs) of Helsinki University Hospital (n = 919) during 2017.
Metformin, the most frequently prescribed medicine for the management of type 2 diabetes, has been shown to reduce cardiovascular events in diabetic patients in pre-clinical and clinical studies. The present work reports the design, synthesis, and biological assessment of the impact of six benzenesulfonamide biguanides on various aspects of hemostasis, cell function, red blood cell integrity (RBC), and their ability to uptake glucose in human umbilical endothelial cells (HUVECs). It was found that all synthesized o- and m-benzenesulfonamides, particularly derivatives with nitro (3) and amino groups (4), are characterized by a good safety profile in HUVECs, which was further confirmed in the cellular integrity studies.
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- The study aimed to compare the effectiveness of brain imaging techniques (DTI, 1H-MRS), serum NSE, and motor scores in predicting poor neurological outcomes in comatose patients after out-of-hospital cardiac arrest.
- Results showed that the predictive accuracy of these methods was not significantly better than the motor score alone, although combining data from multiple methods slightly improved accuracy.
- Ultimately, while there is a small benefit in using advanced imaging together with motor scores and seizures for prediction, the complexity and cost make routine use of DTI/MRS in clinical settings unnecessary.