Publications by authors named "M Hutteman"
Article Synopsis
- - Oesophageal cancer patients achieving a clinical complete response (CR) after neoadjuvant chemoradiotherapy (nCRT) may benefit from active surveillance; however, identifying true CRs is difficult due to a 40% regrowth rate in these patients.
- - The study examined pre-treatment and post-treatment tissue samples to analyze the expression of several tumor markers (CEA, EpCAM, VEGF-α, EGFR, c-MET) through immunohistochemistry, aiming to find markers for potential near-infrared fluorescence imaging.
- - Results showed high expression of EpCAM in adenocarcinomas and EGFR in squamous cell carcinomas, while neoadjuvant therapy did not alter the
Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial.
Lancet Gastroenterol Hepatol
October 2024
Background: Anastomotic leakage is a severe postoperative complication in colorectal surgery and compromised bowel perfusion is considered a major contributing factor. Conventional methods to assess bowel perfusion have a low predictive value for anastomotic leakage. We therefore aimed to evaluate the efficacy of real-time assessment with near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in the prevention of anastomotic leakage.
View Article and Find Full Text PDFBackground: Minimally invasive transcervical oesophagectomy is a surgical technique that offers radical oesophagectomy without the need for transthoracic access. The aim of this study was to evaluate the safety and feasibility of the minimally invasive transcervical oesophagectomy procedure and to report the refinement of this technique in a Western cohort.
Methods: A single-centre prospective cohort study was designed as an IDEAL stage 2A study.
Article Synopsis
- Metastasectomy is a treatment for colorectal lung metastases (CLM), and this study explored using a fluorescent tracer, SGM-101, to improve detection during surgery.
- The study involved 13 patients and measured how effectively SGM-101 indicated the presence of CLM, with the closed-field imaging showing the best results in identifying tumors.
- Ultimately, the findings suggest that SGM-101 has potential for enhancing the surgical targeting of tumors, especially when combined with better imaging technologies and patient selection strategies.
Article Synopsis
- * Conducted a study on 20 patients, using standardized fluorescence videos to derive ten different perfusion parameters based on time-intensity curves, identifying three unique bowel perfusion patterns.
- * Results showed that quantified analysis can effectively differentiate between these perfusion patterns, highlighting the inadequacies of subjective interpretation among surgeons, reflected by a poor-moderate inter-observer agreement.