Publications by authors named "M Hust"
Front Immunol
August 2024
Article Synopsis
- * Cytomegaloviruses (CMVs) can create sustained immune responses, making them promising candidates as vaccine vectors against COVID-19.
- * In a study using a recombinant murine CMV (MCMV) vaccine, not only was robust and long-lasting protection against COVID-19 observed in mice, but it also effectively neutralized variants like Omicron BA.1 after just one dose.
Article Synopsis
- Latrodectism, caused by widow spider bites, leads to severe pain and various health complications, posing a significant global health issue, particularly in developing countries.
- Current treatments include equine serum-derived antivenoms, which have potential risks like allergic reactions, batch variability, and controversial efficacy since latrodectism is seldom fatal.
- Research has developed fully human antibodies that effectively neutralize alpha-latrotoxin from widow spiders, demonstrating potential for safer, more targeted therapies and diagnostics in the future.
Proc Natl Acad Sci U S A
January 2024
Article Synopsis
- The emergence of Omicron subvariants challenges the effectiveness of current vaccines and therapeutic antibodies, leading to increased breakthrough infections linked to weak mucosal IgA responses from mRNA vaccines.
- Researchers engineered new forms of IgA antibodies that showed significantly improved neutralizing abilities against various Omicron lineages compared to traditional IgG antibodies.
- Administering these enhanced IgA antibodies nasally could offer a promising strategy for both preventing and treating Omicron infections, addressing issues of immune evasion by newer variants.
