Publications by authors named "M Husbands"
The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist.
J Pharmacol Exp Ther
February 2000
Article Synopsis
- Muscarinic M1 agonists like WAY-132983 show promise for enhancing cognitive function in Alzheimer's patients by reducing errors caused by scopolamine in various animal models.
- WAY-132983 was linked to significant side effects, such as increased salivation and hypothermia, particularly at higher doses, but cognitive improvements were noted at lower doses.
- The compound demonstrated lasting cognitive benefits in both mice and aged primates, suggesting its potential as a therapeutic option for addressing cognitive deficits in Alzheimer’s disease with manageable side effects.
Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonists as well as templates for the future design of novel dopaminergic agents.
View Article and Find Full Text PDFIdentification of a calcium channel modulator using a high throughput yeast two-hybrid screen.
Nat Biotechnol
October 1998
The interaction of the N-type calcium channel beta3 subunit with the alpha1B subunit alters the activation/inactivation kinetics and the maximal conductance of the channel. The defined protein-protein interaction of the human alpha1B and beta3 subunits provides a target for small-molecule modulation of N-type channel activity. We describe a high throughput screen based on a counterselection yeast two-hybrid assay, which was used to identify small molecules that disrupt alpha1B-beta3 subunit interactions and inhibit N-type calcium channel activity.
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