Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40.

A rhesus monkey experimentally inoculated with simian immunodeficiency virus (SIV) mac251 was killed 42 months later because of poor general condition. CD4 lymphocyte count which was 3,430/mm3 before inoculation, had decreased to 638/mm3 2 months before death. Neuropathological examination revealed changes characteristic of progressive multifocal leukoencephalopathy (PML) in the white matter of the cerebral hemispheres and brain stem.

[Morphometric study of the wall of the caudal vena cava after the implantation of a filter in the sheep].

The long stabilizers of the VT-LGM filter rest on large areas of the vascular wall. The morphometric study of the layers of the vascular wall, after implantation of filter in 15 ewes, divided into 3 groups of follow-up (2, 4 or 8 weeks) of 5 animals, was made at 3 levels opposite the filter and 1 level outside of it. Changes are seen for all the layers.

Caval incorporation of the LGM Vena Tech filter: an experimental study.

Purpose: To analyze LGM Vena Tech filter incorporation and the rapidity of the process.

Materials And Methods: A filter was inserted into the infrarenal inferior vena cava (IVC) of 15 ewes assigned to one of three groups depending on the length of follow-up (2, 4, or 8 weeks). Radiologic data concerning IVC diameter and filter patency, stability, and incorporation were obtained before and after insertion and before euthanasia.

[Contribution of animal models in the understanding of AIDS encephalopathy].

The neuropathology associated with HIV (Human Immunodeficiency Virus) infection is one of the major complications of this disease. The virological and cellular mechanisms by which HIV infection induces motor and cognitive disorders remain unknown. This lack of understanding of the pathophysiology is partly due to the difficulty of experimental analysis in man because only post-mortem samples from terminal phases of the disease and cerebrospinal fluid samples are available.

Virus load and neuropathology in the FIV model.

The FIV (feline immunodeficiency virus) induces in cats brain changes presenting similarities with those observed in human immunodeficiency virus infection. This FIV model was used to study the relationship between viral load in brain, in lymphoid organs and central nervous system (CNS) changes during the early and late stages of infection. Early brain changes were analyzed in animals experimentally infected with two different FIV isolates and sacrificed at 7 and 15 days, 1, 2, 6, and 12 months post inoculation (p.