Publications by authors named "M Hurkacz"
Resistin concentrations in perivascular adipose tissue as a highly sensitive marker of smoking status in patients with advanced coronary artery disease requiring coronary artery bypass grafting.
Front Public Health
December 2024
Article Synopsis
- Smoking significantly increases resistin concentrations in perivascular adipose tissue (PVAT) among coronary artery disease (CAD) patients, with ever-smokers showing notably higher levels than never-smokers.
- The study involved 110 CAD patients scheduled for coronary artery bypass grafting (CABG), categorized by smoking status (never, current, and past smokers), with resistin and inflammatory markers measured.
- Findings indicate a strong correlation between smoking history (pack-years), plasma resistin, and inflammatory markers (IL-6, hs-CRP), highlighting the negative impact of smoking on endothelial function and fat tissue biology in CAD patients.
Introduction: Decongestion is a therapeutic target in acute heart failure (AHF). Acetazolamide is a diuretic that decreases proximal tubular sodium reabsorption, and may also reverse hypochloremia Objectives: We assessed the decongestive, natriuretic, and chloride‑regaining effects as well as the renal safety profile of oral acetazolamide (250 mg) used as an add‑on therapy in patients with AHF.
Patients And Methods: This prospective, randomized study was conducted at the Institute of Heart Diseases in Wrocław, Poland.
Background: Although vascular endothelial growth factor C (VEGF-C) is a known lymphangiogenesis modulator, its relationship with congestion formation and outcomes in acute heart failure (AHF) is unknown.
Methods: Serum VEGF-C levels were measured in 237 patients hospitalized for AHF. The population was stratified by VEGF-C levels and linked with clinical signs of congestion and outcomes.
Aims: Diuretic response in heart failure is blunted when compared to healthy individuals, but the pathophysiology underlying this phenomenon is unclear. We aimed to investigate whether the diuretic resistance mechanism is related to insufficient furosemide tubular delivery or low tubular responsiveness.
Methods And Results: We conducted a prospective, observational study of 50 patients with acute heart failure patients divided into two groups based on previous furosemide use (furosemide naïve: n = 28 [56%] and chronic furosemide users: n = 22 [44%]).
Background: The development of coronary artery disease (CAD) is related to the impaired quantity and composition of inflammatory proteins found in plasma and tissue, such as interleukin 6 (IL-6), adipokines, and resistin. Therefore, the level of plasma resistin in patients with advanced CAD could be indicative of the condition of epicardial adipose tissue and thus have an impact on the frequency and severity of postoperative complications in the form of paroxysmal atrial fibrillation.
Methods: The study included 108 patients who qualified for elective coronary artery bypass grafting (CABG) surgery from 2017 to 2020 and were categorized into two groups.