The evaluation of quantity and distribution of murine pulmonary mast cells in experimental hemorrhagic shock.

Respiratory failure is one of the most serious clinical complications in the course of post-hemorrhagic changes. Cascade-like, systemic inflammatory reaction including the axis: intestines-liver-lung-immune system has a special significance in the pathogenesis of this syndrome. In order to broaden the knowledge of the respiratory insufficiency pathogenesis in hemorrhagic shock, the attempt was made to evaluate quantitatively rat mast cells localized under the pulmonary pleura, around the bronchi, around large vessels and placed in the interalveolar septa.

The evaluation of murine pleural lavage fluid cellular composition in experimental hemorrhagic shock with special regard to mast cells morphometry.

In the course of a hemorrhagic shock, pathological changes occur, which result in intensifying the insufficiency of various vital organs. It can also lead to the development of the multiorgan dysfunction syndrome (MODS) that is the cause of high posthemorrhagic mortality. As a result of the ischemia in the lung there appear proinflammatory factors that mobilize and activate mast cells, inducing degranulation in them.

[The role of pulmonary mast cells in hemorrhagic shock].

In the course of hemorrhagic shock there are multidirectional organ changes that result in intensified disfunction of important organs as well as multiorgan insufficiency syndrome. The syndrome is a cause of high posthemorrhagic mortality. The general inflammatory reaction of intestine--liver--lungs--immunological system increases in a cascadical way and has a significant role in the pathogenesis of the syndrome.