Publications by authors named "M Houssein"
S6 Kinase 2 (S6K2) is a key regulator of cellular signaling and is crucial for cell growth, proliferation, and survival. This review is divided into two parts: the first focuses on the complex network of upstream effectors, downstream modulators, and post-translational modifications (PTMs) that regulate S6K2 activity. We emphasize the dynamic nature of S6K2 regulation, highlighting its critical role in cellular homeostasis and its potential as a therapeutic target in diseases like cancer.
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- - This study evaluated the effectiveness of plasma and urinary metanephrines as diagnostic tools for adrenal lesions in 152 patients, highlighting their importance in a multidisciplinary medical setting.
- - A variety of adrenal conditions were identified among patients, including pheochromocytoma and adrenocortical carcinoma, with 94 patients undergoing surgery.
- - Urinary fractionated metanephrine was found to be the most sensitive test for diagnosing pheochromocytoma (90%), while plasma free normetanephrine was the most specific (91.4%), demonstrating a significant correlation between the plasma and urinary tests.
Purpose: ChatGPT has the potential to offer patient-friendly support. Thyroid carcinoma has become increasingly prevalent in recent years. This study aimed to assess ChatGPT's accuracy and adequacy in answering questions about information, management, and emotional support related to thyroid cancer.
View Article and Find Full Text PDFGrowth or death? Control of cell destiny by mTOR and autophagy pathways.
Prog Biophys Mol Biol
December 2023
Article Synopsis
- - mTOR (mammalian target of rapamycin) is a key regulator of cell growth and metabolism, existing in two complexes: mTORC1, which responds to nutrient availability and is inhibited by rapamycin, and mTORC2, which is not activated by dietary conditions.
- - mTORC1 and mTORC2 play vital roles in processes such as protein synthesis, gene regulation, and apoptosis, as well as autophagy, which helps recycle damaged molecules during nutrient scarcity.
- - The mTOR pathway is often activated in tumors, and its dysregulation is linked to diseases like cancer. Using mTOR inhibitors to control autophagy presents a possible treatment strategy.
DPPA4 is essential for the pluripotent stem cell state, yet its function is poorly understood. DPPA4 is localized in the nucleus, where it is associated with active chromatin. We now report that it is also present in the cytosol, where it appears as diffused clouds, distinct foci and sometimes as spaghetti-like structures.
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