Association between the gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults.

Unlabelled: The concept of genome-microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates the local microbiota, is important in the pathogenesis of human disease. In otolaryngology, the resident bacterial microbiota is reportedly altered in non-infectious ear diseases, such as otitis media pearls and exudative otitis media. We hypothesized that a single-nucleotide polymorphism in the ATP-binding cassette sub-family C member 11 () gene, which determines earwax properties, regulates the ear canal microbiota.

Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice.

Gut bacteria play pivotal roles in the antitumor effects of immune checkpoint inhibitors (ICIs). However, antimicrobial therapy, often necessary for infections in cancer patients, can reduce the efficacy of ICIs. The potential of probiotics to restore ICI efficacy remains uncertain.

Application of the first exit time stochastic model with self-repair mechanism to human mortality rates.

The purpose of this study is to construct a mortality model that reasonably explains survival curves and mortality rates in terms of the decline in biological function, which is the phenomenon of ageing. In this model, an individual organism is regarded as a collection of subsystems, and for each subsystem, the model defines human mortality by introducing positive self-repair mechanisms and stochastically generated negative external shocks. The probability density function of the time of death is derived explicitly, and the model parameters are estimated using life tables from Japan and the UK, which demonstrate the existence of multiple parameter sets that fit well with the observed data.

Ostruthin, a TWIK-Related Potassium Channel Agonist, Increases the Body Temperature in Ovariectomized Rats With or Without Progesterone Administration.

Background And Objectives: The TWIK-related potassium (TREK) channel subfamily, including TREK1 and TREK2, is a novel cold receptor. Ostruthin, a TREK1 and TREK2 agonist, is a component found in the plant and is traditionally used as an anticancer medicine in Vietnam, with its stems and roots treating various ailments. The female hormone progesterone (P4) influences body temperature in women; however, the effect of P4 on thermoregulation via TREK has not been examined.