Publications by authors named "M Horvathova"
Background: Aging induces degenerative processes in the body, contributing to the onset of various age-associated diseases that affect the population. Inadequate dietary habits and low physical activity are major contributors to increased morbidity during aging. This study aimed to investigate the combined effects of omega-3 fatty acid supplementation and physical activity on the markers of oxidative stress and antioxidant defense mechanisms in aged male Wistar rats (23-24 months).
View Article and Find Full Text PDFPEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production.
Int J Nanomedicine
January 2025
Purpose: Our study aimed to assess the effects of anticancer 4-thiazolidinone-based free water-insoluble therapeutics Les-3288 and Les-3833 and their waterborne complexes with branched PEG-containing polymeric carriers (A24-PEG550 and A24-PEG750) on immune response.
Methods: Human peripheral blood was used to study in vitro lymphocyte proliferative function, leukocyte phagocytic activity and respiratory burst, and cytokine production.
Results: The binding of the polymer to the anticancer drug Les-3288, which is intended to mitigate the immunosuppressive effects of the free drug on the proliferative activity of T lymphocytes and T-dependent B cells, demonstrated comparable efficacy for both A24-PEG750 and A24-PEG550 nanocarriers.
This study aims to investigate the in vitro effects of nanoparticles (NPs) produced during the selective laser melting (SLM) of 316 L stainless steel metal powder on the immune response in a human blood model. Experimental data did not reveal effect on viability of 316 L NPs for the tested doses. Functional immune assays showed a significant immunosuppressive effect of NPs.
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- Oxidative stress and inflammation are linked to the development and persistence of metabolic syndrome (MetS) in a study of 170 women aged 40 to 45, categorized based on MetS components.
- The research found differences in oxidative damage and inflammation markers among groups, with healthier controls showing better results compared to those with MetS.
- Key inflammatory markers like C-reactive protein and interleukin-6 were repeatedly associated with MetS components, suggesting that inflammation plays a crucial role early on, while oxidative stress becomes more pronounced with advanced disease.
Article Synopsis
- * Initial thoughts suggested a hidden increase in red blood cells due to increased plasma volume, but tests showed that red cell mass was normal, indicating no erythrocytosis was occurring.
- * Further analysis of 45 OSA patients showed that while there was some increased production of red blood cells (erythropoiesis), it was counteracted by the breakdown of new red blood cells (neocytolysis) and inflammation-related mechanisms that limited iron for red blood cell production, especially after using