Publications by authors named "M Horvath"
In this review, we focus on the biophysical and structural aspects of the oligomeric states of physiologically intrinsically disordered proteins and peptides tau, amyloid-β and α-synuclein and partly disordered prion protein and their isolations from animal models and human brains. These protein states may be the most toxic agents in the pathogenesis of Alzheimer's and Parkinson's disease. It was shown that oligomers are important players in the aggregation cascade of these proteins.
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- The Linearbandkeramik (LBK) Neolithic communities were pioneers in spreading agriculture across Europe and this study showcases genetic data from 250 individuals to understand their ancestry.
- The findings reveal a notable difference in ancestry, with eastern LBK sites having a higher percentage of western hunter-gatherer genetics compared to western sites, indicating separate genetic paths for these groups.
- Additionally, the research suggests a patrilocal social structure, featuring more genetic connections among males within sites, and points out that the massacre at Asparn-Schletz likely involved individuals from a large population rather than a small community.
Article Synopsis
- - MICAL proteins are essential for controlling actin filaments in cells, affecting important processes such as cell shape, division, and nerve growth, but their activity needs careful regulation to avoid harmful changes in cell structure.
- - Previous research hinted that MICAL proteins are kept inactive (autoinhibited) and need specific proteins (Rab proteins) to activate, but the exact details weren't clear until now.
- - The study unveils the structure of MICAL1, revealing how its activation relies on internal interactions within the protein and connections with other protein domains, highlighting a similar mechanism across different MICAL proteins.
Article Synopsis
- Pancreatic cysts vary in their risk of cancer, making it important to differentiate between mucinous and non-mucinous types, as mucinous cysts can become malignant.
- This study compares the effectiveness of measuring intracystic glucose and carcinoembryonic antigen (CEA) levels using endoscopic ultrasound for diagnosing these cysts, involving data from 91 patients who had fine-needle aspiration.
- Results showed that while intracystic glucose is highly sensitive (96.2%) for identifying mucinous cysts, its specificity (79.5%) is lower compared to CEA, which is very specific (100%) but less sensitive (69.2%).
Objectives: To identify the prevalence of depression, anxiety, and psychosocial distress among Ugandan palliative care providers during the COVID-19 pandemic, measure providers' perceived levels of social support, and identify factors affecting a provider's likelihood of being depressed, anxious, distressed, or perceiving various levels of social support.
Methods: Data was collected from 123 palliative care providers using an online survey. Depression, anxiety, and psychological distress were measured using the Patient Health Questionnaire-9, the Generalized Anxiety Disorder-7, and the Self-Reporting Questionnaire, respectively.