Hyaline globules reacting positively with zidovudine antibody in brain and spinal cord of AIDS patients.

Histology of the central nervous system in nine AIDS showed extracellular hyaline globules in the white matter of the brain and the spinal cord. In immunohistochemical studies with a battery of antibodies, the only positive reaction of these globules was with an antibody to zidovudine. High-performance liquid chromatography showed the presence of a zidovudine isomer in eluates of brain tissue from these patients.

[Pharmacologic studies with pentamidine aerosol in HIV patients].

1. After multiple intravenous and inhaled application of pentamidine a steady state of plasma concentrations and of urinary excretion amounts is suggested to occur between the sixth and eighth day of the treatment. An elimination half life of at mean four days and a great volume of distribution of greater than 100 l/kg body weight could be evaluated.