Benefits of the "worst-case scenario": a multi-level examination of the effects of confronting the feared outcome during imagery-based exposure.

Exposure therapy is an efficacious treatment for anxiety-related disorders. Yet, fear often returns after treatment. Occasional reinforcement, in which the feared stimulus is intermittently presented during extinction, increases safety learning and slows fear renewal in conditioning paradigms and analogue samples, but no studies to date have examined this strategy in clinical samples.

Step Edge Defects Have Nanoscale Impact on the Electronic Structure in Semiconducting Transition Metal Dichalcogenide Electrocatalysts.

This work uses MoTe single crystals to address the challenge in heterogeneous catalysis of identifying active sites and determining the electronic factors responsible for catalytic activity. We find that for semiconducting MoTe, spots that fall along step edges show more catalytic activity than spots that fall solely on the basal plane. In contrast, for a semimetallic phase of MoTe, there is no measurable difference between the H evolution activity at the step edges and at the basal plane, indicating that the active sites for H evolution catalysis on transition metal dichalcogenides are phase dependent.

LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis.

Unlabelled: Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis, which is characterized by increased collagen production by activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown to facilitate collagen production. However, LARP6 expression and functionality as a regulator of fibrosis development in a disease relevant model remains elusive.

A novel microsatellite instability test of sebaceous tumours to facilitate low cost universal screening for Lynch syndrome.

Background: One in five sebaceous tumour (ST) patients may have Lynch syndrome (LS), a hereditary cancer predisposition. LS patients benefit from cancer surveillance and prevention programmes and immunotherapy. Whilst universal tumour mismatch repair (MMR) deficiency testing is recommended in colorectal and endometrial cancers to screen for LS, there is no consensus screening strategy for ST, leading to low testing rates and inequity of care.

Mouse pulmonary response following solid surface composite dust inhalation.

: Pulmonary exposure to emissions from manipulating solid surface composite (SSC) materials has been associated with adverse health effects in humans and laboratory animals. Previous and investigations of SSC toxicity have been limited by particle delivery methods that do not fully recapitulate the workplace environment. This study sought to determine the acute SSC-induced pulmonary responses whole-body inhalation exposure.