A deep learning model for inter-fraction head and neck anatomical changes in proton therapy.

To assess the performance of a probabilistic deep learning based algorithm for predicting inter-fraction anatomical changes in head and neck patients.A probabilistic daily anatomy model (DAM) for head and neck patients DAM (DAM) is built on the variational autoencoder architecture. The model approximates the generative joint conditional probability distribution of the repeat computed tomography (rCT) images and their corresponding masks on the planning CT images (pCT) and their masks.

Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties.

Background And Purpose: Erectile dysfunction is a common side effect of radiotherapy for prostate cancer. To mitigate this toxicity, it has been suggested to limit the dose to critical nerves and vessels. We investigated the feasibility of sparing the neuro-vascular bundles (NVBs) in stereotactic body radiotherapy under the impact of realistic treatment uncertainties.

Treatment-related toxicity, utility and patient-reported outcomes of head and neck cancer patients treated with proton therapy: A longitudinal study.

Objective: In comparison to current standard photon irradiation, proton therapy (PT) significantly reduces dose to the surrounding normal tissue and therefore is expected to reduce toxicity and improve health related quality of life (HRQoL). Despite the high expectations of PT, there is very limited data on patients' HRQoL after radiotherapy. This study evaluated HRQoL in head and neck cancer (HNC) patients receiving PT and established a robust benchmark for future comparison of PT and the radiotherapy advancements.

First-in-Men Online Adaptive Robotic Stereotactic Body Radiation Therapy: Toward Ultrahypofractionation for High-Risk Prostate Cancer Patients.

Purpose: Ultrahypofractionation presents challenges for a subset of high-risk prostate cancer patients due to the large planning target volume (PTV) margin required for the seminal vesicles. Online adaptive radiation therapy could potentially reduce this margin. This paper focuses on the development, preclinical validation, and clinical testing of online adaptive robotic stereotactic body radiation therapy for this patient group.

Characterisation of the HollandPTC R&D proton beamline for physics and radiobiology studies.

HollandPTC is an independent outpatient center for proton therapy, scientific research, and education. Patients with different types of cancer are treated with Intensity Modulated Proton Therapy (IMPT). Additionally, the HollandPTC R&D consortium conducts scientific research into the added value and improvements of proton therapy.