A comparative study of 4-hook anchor device with methylene blue for preoperative pulmonary nodule localization.

Background: Accurate localization of small pulmonary nodules (SPNs) during video-assisted thoracoscopic surgery (VATS) is challenging due to the small size and deep location. Both the 4-hook wire technique and methylene blue are significant methods for preoperative localization of SPNs. This study aimed to compare the safety of both methods by monitoring and recording any surgery-related complications.

Design and evaluation of a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma.

The combination of chemotherapy and photothermal therapy not only improves the therapeutic effect but also limits the side effects of drugs. Herein, a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma was designed by utilizing alendronate sodium as a bone-targeting ligand for the targeted delivery of doxorubicin (DOX) loaded polydopamine nanoparticles (PDA NPs) coated with γ-polyglutamic acid (APC@PDA/DOX NPs). The average size of spherical NPs was 140.

Comprehensive Analysis Reveals That ISCA1 Is Correlated with Ferroptosis-Related Genes Across Cancers and Is a Biomarker in Thyroid Carcinoma.

Background: (Iron-Sulfur Cluster Assembly 1) is involved in the assembly of iron-sulfur (Fe-S) clusters, which are vital for electron transport and enzyme activity. Some studies suggest the potential involvement of in tumor progression through interactions with ferroptosis-related genes (FRGs) and the tumor immune microenvironment (TME). However, there has been no systematic analysis of its role in FRGs and the TME or its predictive value for prognosis and immunotherapy response across different cancer types.

First report of a leaf spot disease caused by on L. in Heilongjiang Province, China.

Blue honeysuckle (Lonicera caerulea L.) has been widely used in food, medicine, health products, cosmetics, materials, and other products. Between September 2022 and September 2023, a leaf spot disease was observed on approximately 20% of blue honeysuckle plants of the 'Lanjingling' cultivar grown in a 0.

Parallelization of particle-based reaction-diffusion simulations using MPI.

Particle-based reaction-diffusion models offer a high-resolution alternative to the continuum reaction-diffusion approach, capturing the discrete and volume-excluding nature of molecules undergoing stochastic dynamics. These methods are thus uniquely capable of simulating explicit self-assembly of particles into higher-order structures like filaments, spherical cages, or heterogeneous macromolecular complexes, which are ubiquitous across living systems and in materials design. The disadvantage of these high-resolution methods is their increased computational cost.