Publications by authors named "M Honzumi"

Article Synopsis
  • Activation of the mineralocorticoid receptor (MR) has been linked to cardiovascular diseases, making MR blockers like esaxerenone important for treatment.
  • Esaxerenone has shown strong effects in lowering blood pressure and protecting kidney function in salt-sensitive hypertensive rats, demonstrating its potential as a therapeutic option.
  • The study revealed a unique way esaxerenone binds to the MR ligand-binding domain, providing new insights into its effectiveness compared to other MR antagonists.
View Article and Find Full Text PDF

[reaction in text] A diastereocontrolled route to the eight aldohexoses has been developed starting from a common cyclohexanoid chiral building block.

View Article and Find Full Text PDF

Two children with intractable fecal incontinence after correction of high anorectal malformations were successfully managed by the daily administration of a glycerin enema into the cecum via an appendicocecostomy or tubularized cecostomy, according to the method of Malone's antegrade continence enema (ACE). Fluoroscopic defecography performed during this procedure in each patient disclosed that the glycerin enema promptly evoked cecal peristalsis, which was transmitted to the distal colon and rectum, and squeezed out almost all the fecal matter, evacuating it from the anus. However, two enemas within a short interval were required to achieve a complete washout of feces.

View Article and Find Full Text PDF

We describe herein the case of a 3-year-old child in whom a jejunoileal fistula was caused by the ingestion of magnets. This case report demonstrates that if more than one magnet is found as a foreign body in the intestine, they should not be left untreated even if there are no sharp edges and, it seems they could be evacuated spontaneously. This recommendation is made because the magnets will attract each other and hold the intestinal walls between them, causing necrosis and resulting in intestinal perforation or a fistula.

View Article and Find Full Text PDF