Comparative Genomics of Isolates from the West Bank and Germany Support Molecular Epidemiology of Legionnaires' Disease.

is an environmental bacterium and clinical pathogen that causes many life-threating outbreaks of an atypical pneumonia called Legionnaires' disease (LD). Studies of this pathogen have focused mainly on Europe and the United States. A shortage in data is clearly observed for developing countries.

Whole-genome sequencing of the clinical isolate of ALAW1 from the West Bank allows high-resolution typing and determination of pathogenicity mechanisms.

Background: is water-based bacterium causing Legionnaires' disease (LD). We describe the first documented case of nosocomial LD caused by sequence type (ST) 461 and serogroup 6. The etiology of LD was confirmed by culturing the bronchoalveolar lavage sample retrieving strain ALAW1.

Cytotoxicity, Intracellular Replication, and Contact-Dependent Pore Formation of Genotyped Environmental Isolates from Hospital Water Systems in the West Bank, Palestine.

is the causative agent of Legionnaires' disease. Due to the hot climate and intermittent water supply, the West Bank, Palestine, can be considered a high-risk area for this often fatal atypical pneumonia. occurs in biofilms of natural and man-made freshwater environments, where it infects and replicates intracellularly within protozoa.

Biogeography and Environmental Drivers of Abundance and Genotype Composition Across the West Bank: Relevance of a Genotype-Based Ecology for Understanding Occurrence.

The West Bank can be considered as a high-risk area for prevalence in drinking water due to high ambient temperature, intermittent water supply, frequent pressure loss, and storage of drinking water in roof containers. To assess occurrence of species, especially , in the drinking water of the West Bank, the drinking water distribution systems of eight hospitals were sampled over a period of 2.3 years covering the seasonal cycle and the major geographic regions.

Characterization of Populations by Multilocus Variable Number of Tandem Repeats (MLVA) Genotyping from Drinking Water and Biofilm in Hospitals from Different Regions of the West Bank.

The West Bank can be considered a high-risk area for Legionnaires' disease (LD) due to its hot climate, intermittent water supply and roof storage of drinking water. , mostly , are responsible for LD, a severe, community-acquired and nosocomial pneumonia. To date, no extensive assessment of spp and using cultivation in combination with molecular approaches in the West Bank has been published.