Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach.

Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frailty).

Manipulation of metabolism to improve liquid preservation of mammalian spermatozoa.

Reproductive success in mammals hinges on the ability of sperm to generate sufficient energy through cellular metabolism to perform the energy-intensive processes required for fertilisation, including motility, maturation, and oocyte interactions. It is now widely accepted that sperm exhibit metabolic flexibility, utilising a combination of glycolysis and oxidative phosphorylation (supported by the Krebs cycle and other complementary pathways) to meet their energy demands. However, the preferred pathway for energy production varies significantly among species, making it challenging to map species-specific metabolic strategies, particularly in species with high metabolic flexibility, like the ram.

Search for Rare b→dℓ^{+}ℓ^{-} Transitions at Belle.

We present the results of a search for the b→dℓ^{+}ℓ^{-} flavor-changing neutral-current rare decays B^{+,0}→(η,ω,π^{+,0},ρ^{+,0})e^{+}e^{-} and B^{+,0}→(η,ω,π^{0},ρ^{+})μ^{+}μ^{-} using a 711  fb^{-1} data sample that contains 772×10^{6}  BB[over ¯] events. The data were collected at the ϒ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. We find no evidence for signal and set upper limits on branching fractions at the 90% confidence level in the range (3.

A qualitative study investigating the experiences of unmet social needs for children with cerebral palsy and their families: perspectives of parents and clinicians.

Purpose: To explore (i) the impact of unmet social needs on children with cerebral palsy and their families; (ii) enablers-, and (iii) barriers to addressing unmet social needs.

Material And Methods: Eligible participants attended or worked at one of the three Paediatric Rehabilitation Departments including: children with a diagnosis of cerebral palsy; parents/carers; and clinicians. One-on-one interviews were conducted with parents/carers and focus groups with clinicians.

EPIC-CP pilot trial study protocol: a multicentre, randomised controlled trial investigating the feasibility and acceptability of social prescribing for Australian children with cerebral palsy.

Introduction: The social determinants of health contribute to poorer health outcomes for children with cerebral palsy (CP) and are barriers to families accessing health services. At an individual level, social determinants of health are experienced as unmet social needs, for example, unsafe housing conditions. There is emerging evidence that clinical pathways for the systematic identification and referral to services for unmet social needs can support families to address these needs.