Publications by authors named "M Hino"
Purpose: Prophylaxis with recombinant factor VIII (rFVIII) products is the gold-standard treatment for hemophilia A. However, interindividual differences affect the half-life and clearance of rFVIII products. The myPKFiT is a web-based medical-device software program for population pharmacokinetic (PK) simulation of FVIII products to guide accurate FVIII doses and dosing intervals.
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- Getah virus (GETV) is a mosquito-borne virus that affects horses and pigs, causing symptoms like fever and rash, and has been reported in outbreaks primarily in Asia and Oceania.
- A new strain of GETV (22IH8) was isolated from mosquitoes in Nagasaki, Japan in 2022, and genetic analysis shows it is more closely related to strains from China than those found in Japan in the past.
- The current vaccine for horses in Japan (MI-110) is effective against the new strain, suggesting that existing vaccination efforts can still combat this emerging threat.
Comparison of HLA-haploidentical donors with post-transplant cyclophosphamide versus HLA-matched unrelated donors in peripheral blood stem cell transplantation for acute myeloid leukaemia.
Br J Haematol
December 2024
Article Synopsis
- HLA-haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide (PTCy-haplo) is becoming a safer and more available option compared to matched unrelated donor (MUD) transplants for acute myeloid leukemia (AML).
- * A nationwide study found that while PTCy-haplo has a slower hematopoietic recovery and higher infection-related deaths, it also shows lower rates of severe graft-versus-host disease (GVHD) compared to ATG-free MUD transplants.
- * Overall survival rates were similar across all transplant types, suggesting that PTCy-haplo could be a viable option for AML patients lacking an HLA-matched donor.
With sea-level rise, flooding in coastal communities is now common during the highest high tides. Floods also occur at normal tidal levels when rainfall overcomes stormwater infrastructure that is partially submerged by tides. Data describing this type of compound flooding is scarce and, therefore, it is unclear how often these floods occur and the extent to which non-tidal factors contribute to flooding.
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- The silkworm-baculovirus expression vector system (silkworm-BEVS) utilizes the BmNPV virus and silkworms to effectively produce recombinant proteins, which are important for various biotechnological applications.
- Recent advancements in gene knockout techniques have shown promise in increasing protein yield, but gene editing in the large BmNPV genome is typically slow and complex.
- This study developed a two-step Golden Gate Assembly method to quickly create a modified BmNPV bacmid that omits six specific genes, enhancing the efficiency and ease of producing recombinant proteins in silkworms.