Publications by authors named "M Hesham Al-Mekhlafi"
Article Synopsis
- - The World Health Organization reported that about 970 million people globally had a mental disorder in 2019, highlighting the significant burden of mental health issues on individuals and healthcare systems.
- - A survey of 1,394 people in Iraq found that 54.73% had positive attitudes towards mental health, but men and older individuals (46 years and up) were more likely to have negative views.
- - The study indicates that stigma around mental health problems in the Middle East affects treatment and recovery, and emphasizes the need for health education initiatives to challenge these misconceptions, while suggesting further research for better understanding in Iraq.
Objective: Decisions to treat large-vessel occlusion with endovascular therapy (EVT) or intravenous alteplase depend on how physicians weigh benefits against risks when considering patients' comorbidities. We explored EVT/alteplase decision-making by stroke experts in the setting of comorbidity/disability.
Methods: In an international multi-disciplinary survey, experts chose treatment approaches under current resources and under assumed ideal conditions for 10 of 22 randomly assigned case scenarios.
Background: Some patients with ischemic stroke have poor outcomes despite small infarcts after endovascular thrombectomy, while others with large infarcts sometimes fare better.
Aims: We explored factors associated with such discrepancies between post-treatment infarct volume (PIV) and functional outcome.
Methods: We identified patients with small PIV (volume ≤ 25th percentile) and large PIV (volume ≥ 75th percentile) on 24-48-h CT/MRI in the ESCAPE randomized-controlled trial.
The glomerulus functions as the filtration unit of the kidney. The mesangial, endothelial, and podocyte cells of the glomerulus exhibit the three clinically most important cell types, which are involved in diverse pathologic processes. Cell death has hardly been investigated in these cells but may be of critical importance to the pathogenesis of nephrotic syndrome, nephritic syndrome, focal segmental glomerulosclerosis (FSGS), mesangial proliferation, and thrombonic microangiopathy (which involves dysfunction and death of glomerular endothelial cells).
View Article and Find Full Text PDFThe kidney has been studied as an organ to investigate cell death in vivo for a number of reasons. The unique vasculature that does not contain collateral vessels favors the kidney over other organs for the investigation of ischemia-reperfusion injury. Unilateral uretic obstruction has become the most prominently studied model for fibrosis with impact far beyond postrenal kidney injury.
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