Publications by authors named "M Herwerth"
Objectives: Daratumumab, a monoclonal antibody against CD38, is increasingly used in the treatment of multiple myeloma, other hematological malignancies and autoimmune diseases. Little is known about its CNS toxicity. We present a case of a patient with POEMS syndrome (syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) who developed an acute leukoencephalopathy shortly after initiation of therapy with daratumumab.
View Article and Find Full Text PDFArticle Synopsis
- Mature astrocytes are activated after tissue damage and help form glial scars, but their ability to regenerate after injury is usually limited.* -
- In a study, researchers used imaging to observe astrocytes in mice following the targeted removal of certain astrocytes, finding that surrounding astrocytes showed great plasticity and could repopulate lesions effectively.* -
- A specific type of mature astrocyte, called reactive progenitor-like (REPL) astrocytes, not only multiply but also support the migration of new cells to fill in damaged areas, highlighting a potential therapeutic avenue for treating neurological diseases linked to glial issues.*
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2) with numerous subtypes. In the last few decades, there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune functions.
View Article and Find Full Text PDF