Publications by authors named "M Herrera-Cruz"
Seminal fluid proteins (Sfps) modify female phenotypes and have wide-ranging evolutionary implications on fitness in many insects. However, in the Mexican fruit fly, , a highly destructive agricultural pest, the functions of Sfps are still largely unknown. To gain insights into female phenotypes regulated by Sfps, we used nano-liquid chromatography mass spectrometry to conduct a proteomic analysis of the soluble proteins from reproductive organs of .
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- Rab32 is a small GTPase that plays a crucial role in targeting organelles, particularly at ER-mitochondria contact sites, and influencing mitochondrial membrane dynamics.
- The study identified specific MERC proteins, such as TMX1, that are targeted for degradation through Rab32-mediated autophagy, revealing RTN3L as an important effector in this process.
- The authors introduce the term "MAM-phagy" to describe this selective autophagy that degrades mitochondrial-proximal ER membranes, highlighting Rab32's role in regulating cellular degradation pathways.
Mating has profound physiological and behavioural consequences for female insects. During copulation, female insects typically receive not only sperm, but a complex ejaculate containing hundreds of proteins and other molecules from male reproductive tissues, primarily the reproductive accessory glands. The post-mating phenotypes affected by male accessory gland (MAG) proteins include egg development, attraction to oviposition hosts, mating, attractiveness, sperm storage, feeding and lifespan.
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- * Recent research shows that these contacts become more pronounced during stress conditions (like ER stress and nutrient shortages) but decrease when there is excess nutrient supply.
- * Changes in the composition and structure of MAM are linked to important cellular processes and diseases, including cancer, neurodegeneration, and metabolic syndrome.
Article Synopsis
- Research shows that multiple sclerosis (MS) and endoplasmic reticulum (ER) stress elevate levels of Rab32, a small GTPase located in the ER and mitochondria.
- Both active (Q85L) and inactive (T39N) forms of Rab32 are harmful to neurons, with the active form causing mitochondrial division through interaction with Drp1.
- The study suggests that the inactive Rab32T39N may cause mitochondrial movement to halt in neurites due to increased levels of cytosolic calcium, which affects Miro proteins responsible for transporting mitochondria.