Publications by authors named "M Hernandez-Guerra"
Background: A National Registry for Wilson disease (WD) was recently started by the Spanish Association for Study of the Liver (AEEH). We evaluated the genetic data of the patients and the differences between regions and hospitals.
Method: Multicentric observational study from the WD Registry after the first year.
Interventions to improve bowel cleansing in colonoscopy.
Antonio Z Gimeno-García Davinia Sacramento-Luis Rashika Ashok-Bhagchandani David Nicolás-Pérez Manuel Hernández-Guerra
Expert Rev Gastroenterol Hepatol
January 2025
Article Synopsis
- Suboptimal bowel preparation negatively impacts colonoscopy quality, increasing costs and waiting times due to issues like poor tolerance, noncompliance, and ineffective cleansing solutions.
- The review identifies predictive factors for inadequate bowel preparation and discusses targeted interventions, using clinical insights and evidence-based algorithms.
- Personalized strategies and thorough patient interviews are essential for improving preparation outcomes, particularly for those with prior challenges or those new to the procedure.
Background & Aims: Renal dysfunction is prevalent in advanced chronic liver disease (aCLD) and is associated to liver-related death (LRD). This makes a reliable evaluation of renal function (RF) a crucial aspect. RF can be estimated by formulas or measured by gold standard method.
View Article and Find Full Text PDFArticle Synopsis
- Wilson disease is a genetic disorder affecting copper metabolism, primarily linked to mutations in the ATP7B gene, showing a wide range of clinical symptoms among patients.
- A study of 260 patients revealed that some common mutations, particularly p.Met645Arg and p.Gly869Arg, are underreported due to their milder symptoms, leading to a higher estimated prevalence than recorded (1:3,785, suggesting over 10,500 potential cases in Spain).
- The findings indicate that individuals with the p.Met645Arg mutation often have fewer severe symptoms at diagnosis and are more likely to be diagnosed later in life, underscoring the need for increased awareness and early intervention.