Publications by authors named "M Hernandez Regi"

We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification.

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Unilateral hydronephrosis due to obstruction of the uretero-pelvic junction is one of the most common indications for scintigraphic evaluation of the kidneys in the pediatric patient. In these cases, dynamic renal scintigraphy-both standard and after diuretic administration--is a simple and well-established procedure, allowing demonstration of structural and functional abnormalities of the involved kidney, with relatively low radiation dose to the child. Scintigraphic procedures allow the differential diagnosis between obstructive and non obstructive causes as well as an estimation of renal function of the hydronephrotic kidney providing indication for a conservative or a surgical approach.

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