Bleach baths for atopic dermatitis: A systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE.

Background: Bleach bathing is frequently recommended to treat atopic dermatitis (AD), but its efficacy and safety are uncertain.

Objective: To systematically synthesize randomized controlled trials (RCTs) addressing bleach baths for AD.

Methods: We searched MEDLINE, EMBASE, CENTRAL, and GREAT from inception to December 29, 2021, for RCTs assigning patients with AD to bleach vs no bleach baths.

Exploring the acceptability of a digital mental health platform incorporating a virtual coach: The good, the bad, and the opportunities.

Digital Mental Health Platforms offer feasible options to increase access to mental health support. This study aimed to examine the acceptability of a Low Intensity Cognitive Behaviour Therapy Digital Mental Health Platform, containing a Virtual Coach, with University Students ( = 16) and Mental Health Professionals ( = 5). Semi-structured interviews, exploratory focus groups, and inductive thematic analysis were conducted.

Pulsed triple frequency modulation for frequency stabilization and control of two lasers to an optical cavity.

We present a method to stabilize two lasers to an optical cavity using pulsed triple frequency modulation. The setup allows simultaneous Pound-Drever-Hall stabilization, as well as independent frequency control, while removing interference terms that limit the frequency scan range and allowing for smaller modulation depths. A review of single, dual, and triple frequency modulation is also presented in addition to a discussion of how to effectively turn pulsed triple frequency modulation into independent dual frequency modulation for each laser.

A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant.

Objective: Current medicines are ineffective in approximately one-third of people with epilepsy. Therefore, new antiseizure drugs are urgently needed to address this problem of pharmacoresistance. However, traditional rodent seizure and epilepsy models are poorly suited to high-throughput compound screening.

Process intensification for production of Streptococcus pneumoniae whole-cell vaccine.

The available pneumococcal conjugate vaccines provide protection against only those serotypes that are included in the vaccine, which leads to a selective pressure and serotype replacement in the population. An alternative low-cost, safe and serotype-independent vaccine was developed based on a nonencapsulated pneumococcus strain. This study evaluates process intensification to improve biomass production and shows for the first time the use of perfusion-batch with cell recycling for bacterial vaccine production.