Publications by authors named "M Heinrichs"
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of the oxidative phosphorylation complexes. The RNA and protein components of mitoribosomes are encoded on two different genomes (mitochondrial and nuclear) and are assembled into functional complexes with the help of dedicated factors inside the organelle. Defects in mitoribosome biogenesis are associated with severe human diseases, yet the molecular pathway of mitoribosome assembly remains poorly understood.
View Article and Find Full Text PDFThe amygdala is important for human fear processing. However, recent research has failed to reveal specificity, with evidence that the amygdala also responds to other emotions. A more nuanced understanding of the amygdala's role in emotion processing, particularly relating to fear, is needed given the importance of effective emotional functioning for everyday function and mental health.
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- - Social anxiety disorder (SAD) is a common mental health issue that leads to significant fear and anxiety in social contexts, with recent studies focusing on how different parts of the amygdala function during non-threatening situations.
- - Researchers analyzed resting-state fMRI data from 135 participants to explore how brain connectivity relates to social anxiety symptoms, particularly investigating the distinct roles of amygdala subregions and a brain area called the precuneus.
- - While there were no major differences in brain connectivity between individuals with SAD and healthy controls, specific patterns of brain connectivity were found to correlate with the severity of social anxiety symptoms, suggesting important links between brain function and social anxiety regardless of diagnostic classification.
Deep brain stimulation (DBS) of the supero-lateral medial forebrain bundle (slMFB) is associated with rapid and sustained antidepressant effects in treatment-resistant depression (TRD). Beyond that, improvements in social functioning have been reported. However, it is unclear whether social skills, the basis of successful social functioning, are systematically altered following slMFB DBS.
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