PROTEOLYTIC ACTIVITY OF SECRETED PROTEASES FROM PATHOGENIC LEPTOSPIRES AND EFFECTS ON PHAGOCYTOSIS BY MURINE MACROPHAGES.

Leptospirosis is a zoonosis caused by spirochete Leptospira. Pathogenic leptospires evade the Complement System, enabling their survival upon contact with normal human serum in vitro. In a previous study, we demonstrated that proteases secreted by pathogenic leptospires cleave several Complement proteins, including C3 and the opsonins C3b and iC3b.

Digital Technologies in Hereditary Coagulation Disorders: A Systematic Review.

Background:  This systematic review aims to comprehensively survey digital technologies used in the prevention, diagnosis, and treatment of hereditary blood coagulation disorders.

Methods:  The systematic review was performed according to the PRISMA guidelines. A systematic search was conducted on PubMed on January 29, 2024.

Epidemiological situation of bovine and bubaline tuberculosis in the state of Pará, Amazon region of Brazil.

Introduction: Bovine tuberculosis is one of the primary infectious diseases affecting cattle. Although several countries have managed to eradicate this zoonosis it remains endemic and uncontrolled across many countries in Africa, Asia, Latin America, and the Middle East. Brazil launched its national control and eradication program in 2001, and since then, epidemiological studies have been carried out to define optimal control strategies and to enable the management of the process in each region.

Analysis of free-living seabirds from Brazil as potential hosts of Toxoplasma gondii and serological investigation for antibodies against Leptospira spp.

Dispersal patterns of zoonotic pathogens can be strongly influenced by mobility and contact among hosts. Toxoplasma gondii infection has been documented in many avian species, however, there is little information regarding free-living seabird populations. Leptospira can infect domestic and wild animals, with birds being potential carriers of the bacteria.