Publications by authors named "M Heiden"
Introduction: Research has confirmed the safety and comparable seroconversion rates following SARS-CoV-2 vaccination in patients with solid cancers. However, the impact of cancer treatment on vaccine-induced T cell responses remains poorly understood.
Methods: In this study, we expand on previous findings within the VOICE trial by evaluating the functional and phenotypic composition of mRNA-1273-induced T cell responses in patients with solid tumors undergoing immunotherapy, chemotherapy, or both, compared to individuals without cancer.
Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disability globally. International organizations have highlighted an urgent need for improved prevention, diagnosis, and support. However, the evidence base needed to inform this is thought to be limited.
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- Vaccine responsiveness tends to decrease in older adults, complicating efforts to create effective vaccination strategies for infectious diseases in this age group.
- In the VITAL clinical trials, participants of different age groups were given various vaccines, revealing that older adults had lower antibody responses to the primary vaccines compared to younger adults.
- The study also found that about 10% of participants, particularly older males, showed consistently low responses to multiple vaccines, highlighting the need for targeted vaccination strategies for at-risk groups.
Background And Objectives: Haemovigilance (HV) systems aim to improve transfusion outcomes in patients and donor safety. An important question for blood regulators is how to ensure an effective HV system.
Materials And Methods: We retrospectively analysed the HV reports submitted to Paul-Ehrlich-Institut over the last two decades.