Publications by authors named "M Hebrard"
Article Synopsis
- Structural variants (SVs) play a crucial role in genetic differences that relate to traits and diseases, but most research has focused on European populations.
- This study compiles a catalogue of over 73,000 SVs from a diverse group of 8,392 Singaporeans, revealing that about 65% of these SVs are novel and specific to Asian ancestry groups.
- The findings help identify clinically relevant SVs and improve genetic research by addressing biases related to ancestry, which is important for equity and diversity in the field.
Article Synopsis
- * A study analyzed 381 isolates using a genetic typing method, revealing low genetic diversity and high clonal reproduction among populations, indicating potential movement between walnut trees and a latent pathogenic lifestyle.
- * Genetic comparisons showed different patterns between French populations and those from California and Spain, hinting at limited pathogen transmission from overseas but possible links to French vineyards, offering insights into the spread and factors contributing to walnut dieback in France.
Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify the SNF2-family DNA translocase SMARCAL1 as a factor that favors tumor immune evasion by a dual mechanism involving both the suppression of innate immune signaling and the induction of PD-L1-mediated immune checkpoint responses.
View Article and Find Full Text PDFGenomic researchers increasingly utilize commercial cloud service providers (CSPs) to manage data and analytics needs. CSPs allow researchers to grow Information Technology (IT) infrastructure on demand to overcome bottlenecks when combining large datasets. However, without adequate security controls, the risk of unauthorized access may be higher for data stored on the cloud.
View Article and Find Full Text PDFPrecision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world's population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations.
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