Publications by authors named "M Hasselgren"
Article Synopsis
- Inbreeding depression and genetic rescue are essential concepts in conservation biology that focus on maintaining genetic diversity in endangered species.
- A recent study by Quinn et al. analyzed genomic data to assess the effectiveness of translocation as a strategy for genetic rescue in montane red foxes.
- The findings from this research have significant implications for conservation efforts aimed at other threatened species facing similar challenges.
Inbreeding depression has been documented in various fitness traits in a wide range of species and taxa, however, the mutational basis is not yet well understood. We investigate how putatively deleterious variation influences fitness and is shaped by individual ancestry by re-sequencing complete genomes of 37 individuals in a natural arctic fox (Vulpes lagopus) population subjected to both inbreeding depression and genetic rescue. We find that individuals with high proportion of homozygous loss of function genotypes (LoFs), which are predicted to exert a strong effect on fitness, generally have lower lifetime reproductive success and live shorter lives compared with individuals with lower proportion of LoFs.
View Article and Find Full Text PDFIntroduction: The study aimed to compare prevalence of comorbid allergic manifestations and rhinitis, allergy testing and associations with patient-related outcomes in patients with asthma and COPD.
Methods: Cross-sectional study of randomly selected Swedish patients with a doctor's diagnosis of asthma ( = 1291) or COPD ( = 1329). Self-completion questionnaires from 2014 provided data on demographics, rhinitis, allergic symptoms at exposure to pollen or furry pets, exacerbations, self-assessed severity of disease and scores from the Asthma Control Test (ACT) and the COPD Assessment Test (CAT), and records were reviewed for allergy tests.
Purpose: To study risk factors for uncontrolled asthma and insufficient quality of life (QoL) in patients with mild asthma, ie those without preventer treatment.
Patients And Methods: Patients aged 18-75 years with a doctor's diagnosis of asthma randomly selected from primary and secondary care in Sweden. Mild asthma was defined as self-reported current asthma and no preventer treatment.
Article Synopsis
- - The study investigates the relationship between chronic obstructive pulmonary disease (COPD) and other chronic illnesses, using Swedish national health records from 1997 to 2018, focusing on patients diagnosed with COPD among older adults.
- - Results show that individuals diagnosed with COPD had significantly higher risks of developing conditions like chronic heart failure, peripheral arterial disease, and lung cancer both before and after their COPD diagnosis, with notable odds and hazard ratios indicating increased morbidity.
- - The findings suggest that the presence of chronic diseases may increase the risk of COPD, and post-diagnosis, patients may face compounded health challenges including cardiovascular issues, cancer, depression, osteoporosis, and vascular dementia, indicating the need for comprehensive management strategies.