Publications by authors named "M Hashiguchi"
Objective: At our institute, most pediatric patients undergo epilepsy surgery following a thorough presurgical evaluation without intracranial electroencephalography (EEG). We conducted an initial validation of our noninvasive presurgical strategy by assessing the seizure and developmental outcomes of 135 children.
Methods: All 135 pediatric patients were <15 years old, had undergone curative surgery, and were followed for at least 2 years postoperatively.
Sasa senanensis (a dwarf bamboo), an evergreen herbaceous plant native to the cool temperate regions of eastern Asia, endures seasonal temperature fluctuations and significant variations in light intensity typical for understory plants. Following snowmelt in early spring, the light intensity received by Sasa leaves surges, then diminishes as the canopy of upper deciduous trees develops. The current-year leaves of S.
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- Gum arabic is important in the food industry for its ability to stabilize and emulsify, and it also supports the growth of beneficial gut bacteria like Bifidobacterium.
- The two types of gum arabic, Acacia senegal and A. seyal, both have a protein component called arabinogalactan protein (AGP), but they differ in their structure.
- This research identifies a new enzyme that breaks down specific components of A. seyal gum, revealing its structure and showing how Bifidobacterium catenulatum can use these sugars for growth.
Background: The development of newer agents, including anti-CD38 monoclonal antibodies (mAbs), has significantly improved overall survival (OS) in patients with relapsed or refractory multiple myeloma (RRMM). However, the treatment of older patients with RRMM who are transplant-ineligible remains challenging.
Methods: We retrospectively evaluated OS in 78 transplant-ineligible patients with RRMM who were aged ≥ 65 years and treated at our institution between February 2012 and November 2023.
Article Synopsis
- The study investigated the link between the oncometabolite 2-hydroxyglutarate (2HG) and preoperative seizures in patients with gliomas, particularly focusing on those with mutant isocitrate dehydrogenase (IDH) genes.
- It included 196 patients, measuring metabolite concentrations through 3T MR spectroscopy and assessing correlations with patient characteristics and tumor attributes.
- Results showed that IDH-mutant gliomas had a higher prevalence of preoperative seizures (57.8%) compared to IDH-wildtype gliomas (15.2%), and higher levels of 2HG were found in patients with preoperative seizures, suggesting its potential role in seizure activity.