PLSKB: An Interactive Knowledge Base to Support Diagnosis, Treatment, and Screening of Lynch Syndrome on the Basis of Precision Oncology.

Purpose: Understanding the genetic heterogeneity of Lynch syndrome (LS) cancers has led to significant scientific advancements. However, these findings are widely dispersed across various resources, making it difficult for clinicians and researchers to stay informed. Furthermore, the uneven quality of studies and the lack of effective translation of knowledge into clinical practice create challenges in delivering optimal patient care.

Role of lncRNA PVT1 in the progression of urological cancers: Novel insights into signaling pathways and clinical opportunities.

Urologic malignancies, encompassing cancers of the kidney, bladder, and prostate, represent approximately 25 % of all cancer cases. Recent advances have enhanced our understanding of PVT1's crucial functions. Long noncoding RNAs influence both the onset and development of cancer, as well as epigenetic alterations.

Glutaraldehyde cross-linking for improving the techno-functional properties of biopolymeric food packaging films; a comprehensive review.

Biodegradable and/or edible films made from polysaccharides and proteins have gained attention for their potential to replace some traditional packaging materials in the food industry due to their abundance, biodegradability, and nutritional value. Glutaraldehyde (GLA), rapidly reacts with free deprotonated ε-amino groups in proteins, leading to crosslinking (CL) reactions. This review delves into the chemistry of GLA and explores the various biopolymeric food packaging materials crosslinked by GLA.

Per- and poly-fluoroalkyl substances as forever chemicals in drinking water: Unraveling the nexus with obesity and endocrine disruption - A mini review.

Per- and Poly-fluoroalkyl substances (PFASs) are among the substances that have been widely employed across the world due to their distinct features. These chemicals' great stability in the environment and capacity to be released from consumer goods have demonstrated their existence in all matrices. Additionally, the world's attention has been drawn to these substances' direct relation to human health in recent years.

DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target.

Cancers of the gastrointestinal (GI) tract, including colorectal, pancreatic, and hepatocellular carcinomas, represent a significant global health burden due to their high incidence and mortality rates. Doublecortin-like kinase 1 (DCLK1), initially identified for its role in neurogenesis, has emerged as a crucial player in GI cancer progression. This review comprehensively examines the multifaceted roles of DCLK1 in GI cancers, focusing on its structural isoforms, functions in normal and inflammatory states, and contributions to cancer progression and metastasis.